Modeling predicts a connection between sinus vortex effects and aortic compliance

Yasser Aboelkassem; Dragana Savic; Stuart G Campbell

doi:10.1016/j.jtbi.2015.10.037

Modeling predicts a connection between sinus vortex effects and aortic compliance

J Theor Biol. 2016 Jan 21:389:306-9. doi: 10.1016/j.jtbi.2015.10.037. Epub 2015 Nov 14.

Authors

Yasser Aboelkassem¹, Dragana Savic², Stuart G Campbell³

Affiliations

¹ Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: yasser@jhu.edu.
² Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94158, USA.
³ Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.

PMID: 26585547
DOI: 10.1016/j.jtbi.2015.10.037

Abstract

We submit this letter in order to clarify some methodological issues and concerns raised by Spronck et al. (2015) related to our mathematical modeling of aortic valve dynamics during systole Aboelkassem et al. (2015). It is important to note at the outset that these clarifications do not impact the simulation output or conclusions we originally reported in that paper. However, Spronck et al. have led us to recognize some unfortunate omissions and minor typographical errors in the methods portion of our report that, once corrected, will allow others to more easily reproduce and understand our results.

Keywords: Aortic valve dynamics; Sinus vortex; Systemic vascular resistance.

Publication types

Letter
Comment

MeSH terms

Aortic Valve / physiology*
Humans
Models, Cardiovascular*
Systole / physiology*