TCF-1 at the Tfh and Th1 Divergence

Yaping Chen; Di Yu

doi:10.1016/j.it.2015.11.001

TCF-1 at the Tfh and Th1 Divergence

Trends Immunol. 2015 Dec;36(12):758-760. doi: 10.1016/j.it.2015.11.001. Epub 2015 Nov 15.

Authors

Yaping Chen¹, Di Yu²

Affiliations

¹ Molecular Immunomodulation Laboratory, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.
² Molecular Immunomodulation Laboratory, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Victoria 3800, Australia. Electronic address: Di.Yu@monash.edu.

PMID: 26588880
DOI: 10.1016/j.it.2015.11.001

Abstract

Three recent studies provide new insight into the mechanisms that promote the differentiation of antigen-primed T cells into the follicular helper T (Tfh) lineage, revealing a key role for the transcription factor TCF-1 in the regulation of the Bcl6-Blimp-1 axis that mediates the divergence between the Tfh and the Th1 lineages.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Differentiation / physiology
Receptors, CXCR5 / physiology
T Cell Transcription Factor 1 / metabolism*
Th1 Cells / metabolism*
Th1 Cells / physiology*
Transcription Factors / metabolism

Substances

Receptors, CXCR5
T Cell Transcription Factor 1
Transcription Factors