suPAR: The unspecific marker for disease presence, severity and prognosis

Jesper Eugen-Olsen; Evangelos J Giamarellos-Bourboulis

doi:10.1016/j.ijantimicag.2015.10.011

suPAR: The unspecific marker for disease presence, severity and prognosis

Int J Antimicrob Agents. 2015 Dec:46 Suppl 1:S33-4. doi: 10.1016/j.ijantimicag.2015.10.011. Epub 2015 Oct 31.

Authors

Jesper Eugen-Olsen¹, Evangelos J Giamarellos-Bourboulis²

Affiliations

¹ Clinical Research Centre 056, Copenhagen University Hospital Hvidovre, Kettegaard Alle 30, 2650 Hvidovre, Denmark. Electronic address: jespereugenolsen@gmail.com.
² 4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece.

PMID: 26603640
DOI: 10.1016/j.ijantimicag.2015.10.011

Abstract

Investigation of biomarkers that can promptly predict unfavourable outcome of critically illness is an emerging necessity taking into consideration the need for early intervention, the shortage of available beds in intensive care units and the considerable cost of hospitalisation. The most promising biomarker is soluble urokinase-type plasminogen activator receptor (suPAR). Three studies in large populations of critically ill patients and patients admitted to the emergency department have shown that concentrations >12 ng/mL can safely predict unfavourable outcome. This review presents a thorough analysis of the data from these studies.

Keywords: Biomarker; Prognosis; suPAR.

Publication types

Review

MeSH terms

Biomarkers / blood*
Critical Illness*
Humans
Prognosis
Sepsis / diagnosis*
Sepsis / mortality*
Sepsis / pathology
Urokinase-Type Plasminogen Activator / blood*

Substances

Biomarkers
Urokinase-Type Plasminogen Activator