Sexually transmitted infections and viral hepatitides in patients presenting for non-occupational HIV post-exposure prophylaxis: results of a prospective cohort study

Nirojini Sivachandran; Reed A C Siemieniuk; Pauline Murphy; Andrea Sharp; Christine Walach; Tania Placido; Isaac I Bogoch

doi:10.1016/j.ijid.2015.10.001

Sexually transmitted infections and viral hepatitides in patients presenting for non-occupational HIV post-exposure prophylaxis: results of a prospective cohort study

Int J Infect Dis. 2015 Nov:40:142-4. doi: 10.1016/j.ijid.2015.10.001.

Authors

Nirojini Sivachandran¹, Reed A C Siemieniuk¹, Pauline Murphy², Andrea Sharp², Christine Walach², Tania Placido², Isaac I Bogoch³

Affiliations

¹ Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
² Immunodeficiency Clinic, Toronto General Hospital, Toronto, Ontario, Canada.
³ Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Immunodeficiency Clinic, Toronto General Hospital, Toronto, Ontario, Canada; Divisions of Internal Medicine and Infectious Diseases, University Health Network, Toronto General Hospital, 14EN-209, 200 Elizabeth Street, Toronto, ON, Canada M5G 2C4. Electronic address: isaac.bogoch@uhn.ca.

PMID: 26616402
DOI: 10.1016/j.ijid.2015.10.001

Abstract

Data evaluating the screening practices for viral hepatitides and sexually transmitted infections (STIs) in patients presenting for non-occupational HIV post-exposure prophylaxis (nPEP) care are limited. Screening practices and prevalences of viral hepatitides and STIs were evaluated in 126 patients presenting to a dedicated HIV prevention clinic for HIV nPEP. Three patients (2.4%) were diagnosed with chronic hepatitis C infection, 28 (22.2%) did not have surface antibodies in sufficient quantity to confer immunity to hepatitis B, and six (4.8%) were diagnosed with an STI. A multivariate regression model did not predict any demographic or clinical features predictive of HBV non-immunity. Beyond screening for HIV infection, evaluation for viral hepatitides and STIs is an important feature in the care of patients presenting for HIV nPEP.

Keywords: HIV; Hepatitis B; Hepatitis C; PEP; Post-exposure prophylaxis; Sexually transmitted infections.

MeSH terms

Adult
Ambulatory Care Facilities
Anti-HIV Agents / administration & dosage
Anti-HIV Agents / therapeutic use*
Chlamydia Infections / complications
Chlamydia Infections / epidemiology
Cohort Studies
Female
HIV Infections / prevention & control*
Hepatitis B / complications
Hepatitis B / epidemiology
Hepatitis C / complications
Hepatitis C / epidemiology
Hepatitis, Viral, Human / complications
Hepatitis, Viral, Human / epidemiology*
Humans
Male
Middle Aged
Multivariate Analysis
Post-Exposure Prophylaxis*
Prospective Studies
Risk Factors
Sexually Transmitted Diseases / complications
Sexually Transmitted Diseases / epidemiology*
Young Adult

Substances

Anti-HIV Agents