Ibrutinib and idelalisib target B cell receptor- but not CXCL12/CXCR4-controlled integrin-mediated adhesion in Waldenström macroglobulinemia

Haematologica. 2016 Mar;101(3):e111-5. doi: 10.3324/haematol.2015.137265. Epub 2015 Dec 3.

Authors

Martin F M de Rooij¹, Annemieke Kuil¹, Willem Kraan¹, Marie José Kersten², Steven P Treon³, Steven T Pals⁴, Marcel Spaargaren⁵

Affiliations

¹ Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands.
² Deptartment of Hematology, Academic Medical Center, University of Amsterdam, The Netherlands Lymphoma and Myeloma Center Amsterdam - LYMMCARE, The Netherlands.
³ Bing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA, USA.
⁴ Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands Lymphoma and Myeloma Center Amsterdam - LYMMCARE, The Netherlands.
⁵ Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands Lymphoma and Myeloma Center Amsterdam - LYMMCARE, The Netherlands marcel.spaargaren@amc.uva.nl.

No abstract available

Keywords: BCR; CXCR4; Waldenström macroglobulinemia; adhesion; kinase inhibitors.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adenine / analogs & derivatives
Agammaglobulinaemia Tyrosine Kinase
Antineoplastic Agents / pharmacology*
Cell Adhesion / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival / drug effects
Chemokine CXCL12 / genetics
Chemokine CXCL12 / immunology
Gene Expression Regulation, Neoplastic*
Humans
Integrin alpha4beta1 / genetics
Integrin alpha4beta1 / immunology
Molecular Targeted Therapy
Myeloid Differentiation Factor 88 / genetics
Myeloid Differentiation Factor 88 / immunology
Piperidines
Plasma Cells / drug effects*
Plasma Cells / immunology
Plasma Cells / pathology
Protein-Tyrosine Kinases / genetics
Protein-Tyrosine Kinases / immunology
Purines / pharmacology*
Pyrazoles / pharmacology*
Pyrimidines / pharmacology*
Quinazolinones / pharmacology*
Receptors, Antigen, B-Cell / antagonists & inhibitors
Receptors, Antigen, B-Cell / genetics*
Receptors, Antigen, B-Cell / immunology
Receptors, CXCR4 / genetics
Receptors, CXCR4 / immunology
Signal Transduction
Vascular Cell Adhesion Molecule-1 / genetics
Vascular Cell Adhesion Molecule-1 / immunology
Waldenstrom Macroglobulinemia / genetics
Waldenstrom Macroglobulinemia / immunology
Waldenstrom Macroglobulinemia / pathology

Substances

Antineoplastic Agents
CXCL12 protein, human
CXCR4 protein, human
Chemokine CXCL12
Integrin alpha4beta1
MYD88 protein, human
Myeloid Differentiation Factor 88
Piperidines
Purines
Pyrazoles
Pyrimidines
Quinazolinones
Receptors, Antigen, B-Cell
Receptors, CXCR4
Vascular Cell Adhesion Molecule-1
ibrutinib
Protein-Tyrosine Kinases
Agammaglobulinaemia Tyrosine Kinase
Adenine
idelalisib