68Ga-NOTA-Exendin-4 PET/CT in Localization of an Occult Insulinoma and Appearance of Coexisting Esophageal Carcinoma

Clin Nucl Med. 2016 Apr;41(4):341-3. doi: 10.1097/RLU.0000000000001087.

Abstract

A 61-year-old woman with biochemically proven endogenous hyperinsulinemic hypoglycemia and negative conventional imaging underwent 68Ga-NOTA-exendin-4 PET/CT for localization of insulinoma. Focal intense radioactivity in the tail of the pancreas was observed that was subsequently confirmed as insulinoma pathologically after surgical resection. In addition, esophageal carcinoma with lymph node and hepatic metastases was found by FDG PET/CT in the same patient. Neither the primary carcinoma nor the metastases showed increased radioactivity on 68Ga-NOTA-exendin-4 PET/CT.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma / diagnostic imaging*
  • Carcinoma / secondary
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry*
  • Coordination Complexes / pharmacokinetics
  • Esophageal Neoplasms / diagnostic imaging*
  • Esophageal Neoplasms / secondary
  • Exenatide
  • Female
  • Heterocyclic Compounds
  • Heterocyclic Compounds, 1-Ring
  • Humans
  • Insulinoma / diagnostic imaging*
  • Insulinoma / pathology
  • Liver Neoplasms / diagnostic imaging*
  • Liver Neoplasms / secondary
  • Middle Aged
  • Multimodal Imaging
  • Pancreatic Neoplasms / diagnostic imaging*
  • Pancreatic Neoplasms / pathology
  • Peptides / chemical synthesis
  • Peptides / chemistry*
  • Peptides / pharmacokinetics
  • Positron-Emission Tomography
  • Radiopharmaceuticals
  • Tomography, X-Ray Computed
  • Venoms

Substances

  • 68Ga-NOTA-exendin-4
  • Coordination Complexes
  • Heterocyclic Compounds
  • Heterocyclic Compounds, 1-Ring
  • Peptides
  • Radiopharmaceuticals
  • Venoms
  • 1,4,7-triazacyclononane-N,N',N''-triacetic acid
  • Exenatide