Autophagy Devours the Nuclear Lamina to Thwart Oncogenic Stress

Andrew M Leidal; Jayanta Debnath

doi:10.1016/j.devcel.2015.11.016

Autophagy Devours the Nuclear Lamina to Thwart Oncogenic Stress

Dev Cell. 2015 Dec 7;35(5):529-530. doi: 10.1016/j.devcel.2015.11.016.

Authors

Andrew M Leidal¹, Jayanta Debnath²

Affiliations

¹ Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: andrew.leidal@ucsf.edu.
² Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: jayanta.debnath@ucsf.edu.

PMID: 26651287
DOI: 10.1016/j.devcel.2015.11.016

Abstract

A recent study by Dou et al. (2015) in Nature extends the functions of autophagy to the nucleus, where it mediates the degradation of the nuclear lamina upon oncogenic insults to reinforce cellular senescence.

Publication types

Comment

MeSH terms

Animals
Autophagy*
Humans
Nuclear Lamina / metabolism*