Abstract
Utilizing genome-wide association studies (GWASs) to examine the variation in hepatitis C virus (HCV) phenotypes has led to quantum improvements in our understanding of both the genetic basis and the underlying pathogenesis of HCV infection. In this context, the discovery of interferon lambda polymorphisms is unique with far reaching implications that extend well beyond HCV to various other liver and extrahepatic diseases. In this review, we summarize the data on the impact of GWASs on our understanding of HCV disease.
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cryoglobulinemia / etiology
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Cryoglobulinemia / genetics
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Disease Progression
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Genetic Predisposition to Disease
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Genome-Wide Association Study
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Hepatitis C / complications
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Hepatitis C / genetics
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Hepatitis C, Chronic / complications
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Hepatitis C, Chronic / genetics*
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Humans
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Interferons / genetics*
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Interleukins / genetics
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Liver Cirrhosis / etiology
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Liver Cirrhosis / genetics*
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Liver Cirrhosis / surgery
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Liver Transplantation
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Vasculitis / etiology
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Vasculitis / genetics
Substances
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interferon-lambda, human
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IFNL4 protein, human
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Interleukins
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Interferons