Ménétrier's Disease: Its Mimickers and Pathogenesis

J Pathol Transl Med. 2016 Jan;50(1):10-6. doi: 10.4132/jptm.2015.09.15. Epub 2015 Dec 18.

Abstract

Ménétrier's disease is a rare protein-losing hypertrophic gastropathy. Histologically, it can be mistaken for other disorders showing hypertrophic gastropathy. The pathogenesis of Ménétrier's disease is not fully understood; however, it appears that the epidermal growth factor receptor (EGFR) ligand, transforming growth factor alpha, contributes to the pathogenesis of this disorder. In this review, we will discuss disease entities that can mimic Ménétrier's disease and the role of EGFR signaling in Ménétrier's disease.

Keywords: Gastric polyp; Ménétrier’s disease; Transforming growth factor alpha.

Publication types

  • Review