Triglyceride-Lowering Effects of Two Probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia

J Microbiol Biotechnol. 2016 Mar;26(3):483-7. doi: 10.4014/jmb.1512.12018.

Abstract

The triglyceride-lowering effect of probiotics Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 were investigated. Male SD Wistar rats were randomly divided into three groups and fed high-fat diet (HFD), HFD and probiotics (5 X 10(9) CFU/day of L. plantarum KY1032 and 5 X 10(9) CFU/day of L. curvatus HY7601), or normal diet for 6 weeks. Probiotic treatment significantly lowered the elevated plasma triglyceride and increased plasma free fatty acid, glycerol, and plasma apolipoprotein A-V (ApoA-V) levels. The probiotic-treated group showed elevated hepatic mRNA expression of PPARα, bile acid receptor (FXR), and ApoA-V. These results demonstrate that L. plantarum KY1032 and L. curvatus HY7601 lower triglycerides in hypertriglyceridemic rats by upregulating ApoA-V, PPARα, and FXR.

Keywords: Lactobacillus curvatus; Lactobacillus plantarum; Triglyceride; apolipoprotein A-V; probiotics.

MeSH terms

  • Animals
  • Diet, High-Fat / adverse effects
  • Dietary Supplements
  • Disease Models, Animal
  • Humans
  • Hypertriglyceridemia / drug therapy*
  • Hypertriglyceridemia / metabolism
  • Lactobacillus / physiology*
  • Lactobacillus plantarum / physiology*
  • Liver / metabolism
  • Male
  • Probiotics / administration & dosage*
  • Rats
  • Rats, Wistar
  • Triglycerides / metabolism*

Substances

  • Triglycerides