Evaluation of response after neoadjuvant treatment in soft tissue sarcomas; the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG) recommendations for pathological examination and reporting

E Wardelmann; R L Haas; J V M G Bovée; Ph Terrier; A Lazar; C Messiou; C LePechoux; W Hartmann; F Collin; C Fisher; G Mechtersheimer; A P DeiTos; S Stacchiotti; R L Jones; A Gronchi; S Bonvalot

doi:10.1016/j.ejca.2015.09.021

Evaluation of response after neoadjuvant treatment in soft tissue sarcomas; the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG) recommendations for pathological examination and reporting

Eur J Cancer. 2016 Jan:53:84-95. doi: 10.1016/j.ejca.2015.09.021. Epub 2015 Dec 14.

Authors

E Wardelmann¹, R L Haas², J V M G Bovée³, Ph Terrier⁴, A Lazar⁵, C Messiou⁶, C LePechoux⁷, W Hartmann¹, F Collin⁸, C Fisher⁹, G Mechtersheimer¹⁰, A P DeiTos¹¹, S Stacchiotti¹², R L Jones¹³, A Gronchi¹⁴, S Bonvalot¹⁵

Affiliations

¹ Gerhard-Domagk-Institute of Pathology of the University Hospital, Münster, Germany.
² Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address: r.haas@nki.nl.
³ Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
⁴ Department of Medical Biology and Pathology of Gustave Roussy, Villejuif, France.
⁵ Department of Pathology, University of Texas MD Anderson Cancer Center, Houston TX, USA.
⁶ Department of Radiology, The Royal Marsden Hospital, London, UK.
⁷ Department of Radiotherapy, Institut Gustave Roussy, Paris, France.
⁸ Department of Pathology, Centre Georges-Francois Leclerc, Dijon, France.
⁹ Sarcoma Unit, The Royal Marsden Hospital, London, UK.
¹⁰ Institute of Pathology, University of Heidelberg, Germany.
¹¹ Department of Oncology and of Anatomic Pathology, General Hospital of Treviso, Italy.
¹² Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
¹³ Department of Medical Oncology, The Royal Marsden Hospital, London, UK.
¹⁴ Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
¹⁵ Department of Surgery, Institute Curie, Paris, France.

PMID: 26700077
DOI: 10.1016/j.ejca.2015.09.021

Abstract

At present, there is not a commonly used and generally accepted standardized approach for the pathologic evaluation of pretreated soft tissue sarcomas. Also, it is still unclear whether the cut-off for prognostic relevance is similar in the many different histological subtypes of STS. This manuscript, produced by a European Organization for Research and Treatment of Cancer - Soft Tissue and Bone Sarcoma Group (EORTC-STBSG) endorsed task force, aims to propose standardization of the pathological examination process and the reporting of STS resection specimens after neoadjuvant radio- and/or chemotherapy.

Keywords: Chemotherapy; Guideline; Pathology; Radiotherapy; Response evaluation; Soft tissue sarcoma.

MeSH terms

Bone Neoplasms / drug therapy
Bone Neoplasms / pathology*
Bone Neoplasms / radiotherapy
Humans
Immunohistochemistry
Magnetic Resonance Imaging
Microscopy / methods
Neoadjuvant Therapy / methods
Sarcoma / drug therapy
Sarcoma / pathology*
Sarcoma / radiotherapy