[Adult medulloblastoma: Retrospective series of 21 patients]

Abstract

Purpose: Retrospective analysis of the results of 21 adults treated for medulloblastoma.

Patients and methods: Between 1978 and 2011, 21 adults with an average age of 31 years (18.3-50) were treated with surgery then with radiotherapy (n=20) at the Comprehensive Cancer Center of Strasbourg. For some (n=12), treatment consisted of chemotherapy.

Results: After a mean follow-up of 122 months (19-423), six relapses and seven deaths were observed. Overall survival at 5 years and 10 years was 89.4 ± 7.1% for both. Disease-free survival at 5 years and 10 years was 79.6 ± 9.2% and 85.7 ± 7.6% and 60.6 ± 17.7%, respectively.

Conclusion: The rarity of medulloblastoma, especially in adults and these results confirm the necessity of international protocols.

Keywords: Adulte; Adults; Medulloblastoma; Médulloblastome; Radiothérapie.