A new coumarin from stem bark of Mesua hexapetala

Nat Prod Res. 2016 Jul;30(14):1591-7. doi: 10.1080/14786419.2015.1120727. Epub 2015 Dec 28.

Abstract

A new alkylated coumarin derivative, hexapetarin (1) along with three other xanthones, trapezifolixanthone (2), cudraxanthone G (3) and 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone (4), and four common triterpenoids, friedelin (5), stigmasterol (6), beta-sitosterol (7) and gamma-sitosterol (8) were isolated from the stem bark of Mesua hexapetala (Clusiaceae), a plant, native to Malaysia. The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. Anti-inflammatory activity assay indicated hexapetarin (1) to possess moderate anti-inflammatory activity, while 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone (4) gave very good activity.

Keywords: Mesua hexapetala; anti-inflammatory; coumarin; xanthone.

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Cells, Cultured
  • Clusiaceae / chemistry*
  • Coumarins / chemistry*
  • Coumarins / pharmacology
  • Humans
  • Magnetic Resonance Spectroscopy
  • Malaysia
  • Mass Spectrometry
  • Plant Bark / chemistry*
  • Plant Extracts / chemistry
  • Plant Stems / chemistry*
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Coumarins
  • Plant Extracts
  • hexapetarin