The oncogene ETS1 is distant from the chromosome 11 breakpoint in leukaemic cells with the t(11;19)(q23;p13)

Leuk Res. 1989;13(6):459-63. doi: 10.1016/0145-2126(89)90167-7.

Abstract

Field inversion gel electrophoresis of DNA from a leukemic clone characterized by the t(11;19)(q23;p13) allowed us to exclude any genomic rearrangement within more than 900 kb of DNA encompassing ETS1 on chromosome 11. Although ETS1 was moved to the derivative chromosome 19 as a result of the t(11;19), we conclude that this oncogene is not close to the chromosome 11 breakpoint and is unlikely to be involved in this leukaemia.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blotting, Southern
  • Chromosomes, Human, Pair 11 / ultrastructure*
  • Chromosomes, Human, Pair 19 / ultrastructure*
  • DNA, Neoplasm / genetics
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
  • Male
  • Oncogenes*
  • Proto-Oncogene Protein c-ets-1
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-ets
  • Restriction Mapping
  • Transcription Factors*
  • Translocation, Genetic

Substances

  • DNA, Neoplasm
  • ETS1 protein, human
  • Proto-Oncogene Protein c-ets-1
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-ets
  • Transcription Factors