Lethal drugs in capital punishment in USA: History, present, and future perspectives

Res Social Adm Pharm. 2016 Nov-Dec;12(6):1026-1034. doi: 10.1016/j.sapharm.2015.11.009. Epub 2015 Nov 26.

Abstract

Lethal injection is the preferred method for the execution of condemned prisoners in the United States. A recent decision of The European Union to prohibit the export of drugs used in capital punishment to the USA along with domestic firms ceasing to manufacture these drugs has resulted in a drug shortage and a search for alternative drugs and new drug combinations that have not been previously validated for inducing death. As a consequence, some of the executions did not proceed as expected and sparked public debate regarding whether recent executions by lethal injection serve the purpose of avoiding "cruel and unusual punishment" in executions. Moreover, a cottage industry comprised of compounding pharmacies as emerged as a source of drug combinations used in capital punishment. Although there is a growing trend toward the abolishment of capital punishment in United States, the controversy concerning the efficacy of drug and involvement of health care professionals in the execution procedure is far from over.

Keywords: Barbiturates; Capital punishment; Compounding pharmacies; Ethics; Lethal injection; Midazolam mishaps; Pancuronium bromide; Potassium chloride.

MeSH terms

  • Capital Punishment / methods*
  • Capital Punishment / trends
  • Commerce
  • Drug Combinations
  • Drug Compounding
  • Drug Industry
  • European Union
  • Humans
  • Injections, Intravenous
  • Pharmaceutical Preparations / administration & dosage*
  • Pharmaceutical Preparations / supply & distribution
  • Pharmaceutical Services / organization & administration*
  • United States

Substances

  • Drug Combinations
  • Pharmaceutical Preparations