Overexpression of hepatocyte growth factor and an oncogenic CDK4 variant in mice alters corneal stroma morphology but does not lead to spontaneous ocular melanoma

Melanoma Res. 2016 Feb;26(1):89-91. doi: 10.1097/CMR.0000000000000206.

Authors

Marta M Kilian¹, Martina C Herwig, Frank G Holz, Thomas Tüting, Karin U Loeffler

Affiliation

¹ Departments of aOphthalmology bExperimental Dermatology, University of Bonn, Bonn, Germany.

PMID: 26731561
DOI: 10.1097/CMR.0000000000000206

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Corneal Stroma / metabolism
Corneal Stroma / pathology*
Cyclin-Dependent Kinase 4 / genetics*
Cyclin-Dependent Kinase 4 / metabolism
Eye Neoplasms / genetics
Eye Neoplasms / pathology
Gene Transfer Techniques
Hepatocyte Growth Factor / genetics*
Hepatocyte Growth Factor / metabolism
Humans
Melanoma, Experimental / genetics
Melanoma, Experimental / pathology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Oncogenes
Organ Size / genetics
Up-Regulation / genetics

Substances

HGF protein, mouse
Hepatocyte Growth Factor
Cdk4 protein, mouse
Cyclin-Dependent Kinase 4