Correlation between rs198388 and rs198389 polymorphismsin brainnatriuretic peptide (NPPB) gene and susceptibility to congenital heart diseases in a Chinese population

Qing Zhang; Fang-Qi Gong; Wei-Hua Zhu; Chun-Hong Xie; Yi-Ying Zhang; Li-Yang Ying

Correlation between rs198388 and rs198389 polymorphismsin brainnatriuretic peptide (NPPB) gene and susceptibility to congenital heart diseases in a Chinese population

Int J Clin Exp Med. 2015 Oct 15;8(10):19162-6. eCollection 2015.

Authors

Qing Zhang¹, Fang-Qi Gong¹, Wei-Hua Zhu¹, Chun-Hong Xie¹, Yi-Ying Zhang¹, Li-Yang Ying¹

Affiliation

¹ Department of Cardiology, Medical College Affiliated Children Hospital, Zhejiang University Hangzhou 310002, China.

PMID: 26770549
PMCID: PMC4694449

Abstract

Objective: We discussed the correlation between SNP loci (rs198389 and rs198388) in brain natriuretic peptide gene (NPPB) and susceptibility to congenital heart diseases (CHD).

Method: Multiplex SNaPshot technique was adopted for profiling of SNP genotypes at loci rs198389 and rs198388 in NPPB gene among 150 cases of CHDand 150 normal controls.

Results: The distribution frequency of 3 genotypes (AA, AG and GG) at locus rs198389 was 40.7%, 36.0% and 23.3% in CHD group, respectively, showing significant differences compared with the normal controls (P<0.001). Gallele was associated with higher risk of CHD (OR=2.48, 95% CI=1.77-3.48). The distribution frequency of CC, CTand TT genotypes at locus rs198388 was 60.7%, 17.3% and 22.0% in CHD group, respectively, also showing significant differences compared with the normal controls (P<0.001). C allele could increase the risk of CHD (OR=1.92, 95% CI=1.48-2.48).

Conclusion: SNP loci rs198389 and rs198388 in NPPB gene were correlated with genetic susceptibility to CHD.

Keywords: Brain natriuretic peptide (NPPB); congenital heart disease (CHD); genetic susceptibility; single nucleotide polymorphism (SNP).