A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults

Yeimy González-Giraldo; Rodrigo E González-Reyes; Diego A Forero

doi:10.1016/j.psychres.2016.01.006

A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults

Psychiatry Res. 2016 Feb 28:236:202-205. doi: 10.1016/j.psychres.2016.01.006. Epub 2016 Jan 5.

Authors

Yeimy González-Giraldo¹, Rodrigo E González-Reyes¹, Diego A Forero²

Affiliations

¹ Laboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia.
² Laboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia. Electronic address: diego.forero@uan.edu.co.

PMID: 26778630
DOI: 10.1016/j.psychres.2016.01.006

Abstract

MIR137, a brain expressed miRNA, has been identified as a top novel susceptibility gene for schizophrenia (SZ). 230 healthy participants completed the Stroop test and were genotyped for a functional Variable Number Tandem Repeat (VNTR) in MIR137 gene. MIR137 VNTR genotypes were associated with differences in Stroop facilitation and accuracies in congruent trials and for the total number of errors. This is the first study of the functional VNTR in MIR137 gene and Stroop test performance in healthy subjects. Our results could have important implications for the identification of genetic candidates for endophenotypes for SZ.

Keywords: Endophenotypes; Executive function; MicroRNAs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Colombia
Endophenotypes
Female
Genetic Predisposition to Disease*
Genotype
Healthy Volunteers
Humans
Male
MicroRNAs / genetics*
Minisatellite Repeats
Schizophrenia / genetics*
Stroop Test*
Young Adult

Substances

MIRN137 microRNA, human
MicroRNAs