Myelopoiesis Reloaded: Single-Cell Transcriptomics Leads the Way

Joachim L Schultze; Marc Beyer

doi:10.1016/j.immuni.2015.12.019

Myelopoiesis Reloaded: Single-Cell Transcriptomics Leads the Way

Immunity. 2016 Jan 19;44(1):18-20. doi: 10.1016/j.immuni.2015.12.019.

Authors

Joachim L Schultze¹, Marc Beyer²

Affiliations

¹ Life and Medical Science (LIMES) Institute, University of Bonn, 53115 Bonn, Germany; Single Cell Center for Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, 53175 Bonn, Germany. Electronic address: j.schultze@uni-bonn.de.
² Life and Medical Science (LIMES) Institute, University of Bonn, 53115 Bonn, Germany; Single Cell Center for Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, 53175 Bonn, Germany. Electronic address: marc.beyer@uni-bonn.de.

PMID: 26789920
DOI: 10.1016/j.immuni.2015.12.019

Abstract

Lineage commitment during myelopoiesis has been linked to late-stage progenitors with multi-lineage potential. In a recent issue of Cell, Paul et al. (2015) now suggest a much earlier commitment toward distinct lineages even prior to the common myeloid progenitor state.

Publication types

Comment

MeSH terms

Animals
Hematopoiesis*
Myeloid Progenitor Cells / cytology*
Myeloid Progenitor Cells / metabolism*
Single-Cell Analysis*
Transcriptome*