Wheeling and Dealing With Antigen Presentation in Tuberculosis

Denis Hudrisier; Olivier Neyrolles

doi:10.1016/j.tim.2016.01.001

Wheeling and Dealing With Antigen Presentation in Tuberculosis

Trends Microbiol. 2016 Mar;24(3):166-168. doi: 10.1016/j.tim.2016.01.001. Epub 2016 Jan 18.

Authors

Denis Hudrisier¹, Olivier Neyrolles²

Affiliations

¹ CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), 205 route de Narbonne BP 64182, 31000 Toulouse, France; Université de Toulouse, UPS, IPBS, 31000 Toulouse, France.
² CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), 205 route de Narbonne BP 64182, 31000 Toulouse, France; Université de Toulouse, UPS, IPBS, 31000 Toulouse, France. Electronic address: olivier.neyrolles@ipbs.fr.

PMID: 26794467
DOI: 10.1016/j.tim.2016.01.001

Abstract

In tuberculosis, antigens are transferred from infected to uninfected dendritic cells. Does this favor T lymphocyte response and anti-mycobacterial host defense? In a recent report published in Cell Host & Microbe, Ernst and colleagues show that Mycobacterium tuberculosis seems to have hijacked this mechanism for its own benefit.

Keywords: CD4 T cell; MHC class II; antigen presentation; dynamin; kinesin-2; tuberculosis.

Publication types

Comment

MeSH terms

Antigen Presentation*
Antigens, Bacterial / immunology*
CD4-Positive T-Lymphocytes / immunology
Lymphocyte Activation
Mycobacterium tuberculosis
Tuberculosis / immunology

Substances

Antigens, Bacterial