Atrial Natriuretic Peptide in the High Normal Range Is Associated With Lower Prevalence of Insulin Resistance

Amra Jujić; Peter M Nilsson; Margaretha Persson; Jens Juul Holst; Signe Sørensen Torekov; Valeriya Lyssenko; Leif Groop; Olle Melander; Martin Magnusson

doi:10.1210/jc.2015-3518

Atrial Natriuretic Peptide in the High Normal Range Is Associated With Lower Prevalence of Insulin Resistance

J Clin Endocrinol Metab. 2016 Apr;101(4):1372-80. doi: 10.1210/jc.2015-3518. Epub 2016 Jan 27.

Authors

Amra Jujić¹, Peter M Nilsson¹, Margaretha Persson¹, Jens Juul Holst¹, Signe Sørensen Torekov¹, Valeriya Lyssenko¹, Leif Groop¹, Olle Melander¹, Martin Magnusson¹

Affiliation

¹ Departments of Cardiology (A.J., M.M.), Internal Medicine (O.M.), and Clinical Sciences (A.J., P.M.N., M.P., L.G., O.M., M.M.), Skåne University Hospital, SE-205 02 Malmö, Sweden; Department of Clinical Sciences (V.L.), Diabetes and Endocrinology Unit, Lund University Diabetes Center, Lund University, SE-200 41 Malmö, Sweden; Department of Biomedical Sciences and NNF Center for Basal Metabolic Research (J.J.H., S.S.T.), The Panum Institute, DK-2200 Copenhagen, Denmark; and Steno Diabetes Center A/S (V.L.), DK-2820 Gentofte, Denmark.

PMID: 26815880
DOI: 10.1210/jc.2015-3518

Abstract

In 2243 subjects, MR-proANP was measured at baseline. At follow up, MR-proANP levels in the high normal range were associated with lower prevalence of insulin resistance and higher post challenge GIP secretion.

Publication types

Randomized Controlled Trial

MeSH terms

Atrial Natriuretic Factor / blood*
Biomarkers / blood*
Female
Heart Failure / blood*
Heart Failure / physiopathology
Humans
Insulin Resistance*
Male
Middle Aged
Prevalence
Prospective Studies
Reference Values

Substances

Biomarkers
Atrial Natriuretic Factor