Cytokines of the LIF/CNTF family and metabolism

Cytokine. 2016 Jun:82:122-4. doi: 10.1016/j.cyto.2015.12.019. Epub 2016 Jan 23.

Abstract

The incidence of obesity is increasing worldwide. Obesity is accompanied by a chronic inflammatory state that increases the risk of metabolic diseases such as insulin-resistance and type 2 diabetes. Over the past two decades, interest in immunomodulatory cytokines as potential mediators and/or targets for treatment or prevention of obesity and metabolic syndrome has increased. In this review, we summarize studies that revealed the effects of LIF family cytokines on adipose tissue, energy expenditure and food intake, highlighting the importance of gp130/LIFRβ signaling in obesity and obesity-related metabolic diseases.

Keywords: Cytokines; Leukemia inhibitory factor; Metabolism; Obesity; gp130.

Publication types

  • Review
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ciliary Neurotrophic Factor / immunology*
  • Diabetes Mellitus, Type 2 / immunology*
  • Diabetes Mellitus, Type 2 / pathology
  • Humans
  • Leukemia Inhibitory Factor / immunology*
  • Metabolic Syndrome / immunology*
  • Metabolic Syndrome / pathology
  • Obesity / immunology*
  • Obesity / pathology
  • Risk Factors

Substances

  • Ciliary Neurotrophic Factor
  • LIF protein, human
  • Leukemia Inhibitory Factor

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