Viral hepatitis vaccination during pregnancy

Hum Vaccin Immunother. 2016 Apr 2;12(4):894-902. doi: 10.1080/21645515.2015.1132129.

Abstract

Viral hepatitis is a serious global public health problem. It is also a common cause of jaundice and gestational complications in pregnant women. Moreover, infected mothers can transmit the virus to their fetus or neonate, which may increase disease burden and decrease quality of life. To date, commercial vaccines have been developed for hepatitis A, B, and E and are available to the general population. The Advisory Committee on Immunization Practices currently accepts emergency vaccination against hepatitis A and B during pregnancy due to benefits that overweight the potential risks. While there are limited data from trials with limited numbers of samples that suggest the efficacy or safety of hepatitis B and E vaccines in pregnant women, additional data are necessary to provide evidence of vaccination during pregnancy.

Keywords: pregnant women; vaccination; viral hepatitis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Clinical Trials as Topic
  • Female
  • Hepatitis A / prevention & control*
  • Hepatitis A / virology
  • Hepatitis A Vaccines / administration & dosage
  • Hepatitis A Vaccines / adverse effects
  • Hepatitis B / prevention & control*
  • Hepatitis B / virology
  • Hepatitis B Vaccines / administration & dosage
  • Hepatitis B Vaccines / adverse effects
  • Hepatitis E / prevention & control*
  • Hepatitis E / virology
  • Humans
  • Infant, Newborn
  • Pregnancy
  • Pregnancy Complications, Infectious / prevention & control*
  • Pregnancy Complications, Infectious / virology
  • Vaccination / statistics & numerical data
  • Viral Hepatitis Vaccines* / administration & dosage
  • Viral Hepatitis Vaccines* / adverse effects

Substances

  • Hepatitis A Vaccines
  • Hepatitis B Vaccines
  • Viral Hepatitis Vaccines