A case of juvenile papillomatosis involving the supra glottic area of the larynx and the esophagus in a 10 months old infant is reported. The patient was treated by multiple Laser CO2 resections of papillomas and received autogenous vaccine. He is now 5 years; he is well and apparently free of disease for the last two years. Radiography of the larynx and esophagogram were crucial for the initial diagnosis and the followup of this child.