Abstract
A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.
Keywords:
Huisgen 1,3-dipolar cycloaddition; antiviral; nucleosides; triazole.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Cell Line
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Chickenpox / drug therapy
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Cycloaddition Reaction
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Cytomegalovirus / drug effects
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Cytomegalovirus Infections / drug therapy
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Herpesvirus 3, Human / drug effects
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Humans
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Lung / cytology
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Lung / virology
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Purine Nucleosides / chemical synthesis*
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Purine Nucleosides / chemistry
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Purine Nucleosides / pharmacology*
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Triazoles / chemical synthesis*
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Triazoles / chemistry
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Triazoles / pharmacology*
Substances
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Antiviral Agents
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Purine Nucleosides
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Triazoles