Four hepatosplenic T-cell lymphoma cases of Japanese patients

Hidetsugu Kawai; Hiromichi Matsushita; Ken Ohmachi; Minoru Kojima; Shinichiro Machida; Yoshiaki Ogawa; Hiroshi Kawada; Naoya Nakamura; Kiyoshi Ando

doi:10.1016/j.lrr.2015.12.001

Four hepatosplenic T-cell lymphoma cases of Japanese patients

Leuk Res Rep. 2015 Dec 15:5:3-6. doi: 10.1016/j.lrr.2015.12.001. eCollection 2016.

Authors

Hidetsugu Kawai¹, Hiromichi Matsushita², Ken Ohmachi¹, Minoru Kojima¹, Shinichiro Machida¹, Yoshiaki Ogawa¹, Hiroshi Kawada¹, Naoya Nakamura³, Kiyoshi Ando¹

Affiliations

¹ Department of Hematology/Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
² Department of Laboratory Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
³ Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.

Abstract

Hepatosplenic T-cell lymphoma (HSTCL), a rare type of γδ T-cell lymphoma, is characterized by hepatosplenomegaly and cytopenias. It is associated with immunodeficiency and its age of onset is reportedly between the 20s and 30s. We herein report 4 Japanese HSTCL cases. Three of them, including an elderly case that was 74 years of age, were not at adolescence. No cases had a history of immunodeficiency. All other disease phenotypes were similar to the typical HSTCL cases. These findings suggest that there are a certain proportion of HSTCL patients who presented after middle age.

Keywords: Elderly patients; Hepatosplenic T-cell lymphoma; Immunodeficiency.