Enhancing the selectivity of kinase inhibitors in oncology: a chemical biology perspective

Future Med Chem. 2016;8(3):241-4. doi: 10.4155/fmc.15.193. Epub 2016 Feb 22.

Authors

Sean Maddox¹, David Hecht², Jeffrey L Gustafson¹

Affiliations

¹ Department of Chemistry & Biochemistry, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182-1030, USA.
² School of Mathematics, Science & Engineering, Southwestern College, 900 Otay Lakes Road, Chula Vista, CA 91910, USA.

PMID: 26898835
DOI: 10.4155/fmc.15.193

No abstract available

Keywords: chemical probe; drug discovery; kinase inhibition; oncology; target selectivity.

Publication types

Editorial

MeSH terms

Computational Biology
Neoplasms / drug therapy*
Neoplasms / enzymology*
Protein Kinase Inhibitors / chemistry
Protein Kinase Inhibitors / pharmacology*
Protein Kinases / metabolism

Substances

Protein Kinase Inhibitors
Protein Kinases