A test system for influenza diagnosis has been developed on the basis of monoclonal antibodies to influenza A and B virus proteins using the principles of lanthanide immunofluorescence analysis. The diagnostic test system was shown to be highly specific in detecting influenza A and B virions in model systems. For the one-step variant of a double sandwich used in the study, the total time of diagnostic experiment using clinical materials was shown to be reduced to 15-20 min.