Orbital Mass in a Child With Acute Lymphoblastic Leukemia: A Case Report and Review of the Literature

J Pediatr Hematol Oncol. 2016 Nov;38(8):646-648. doi: 10.1097/MPH.0000000000000544.

Abstract

Acute lymphoblastic leukemia arising from lymphoid precursor cells of the bone marrow, the lymphoreticular system, and the soft tissue can present with medullary and extramedullary involvement. Extramedullary involvement has the propensity to affect a multitude of organs. Presentation with proptosis secondary to orbital mass in childhood acute lymphoblastic leukemia (ALL) is very rare. We report a child with pre-B cell ALL with an extramedullary soft tissue mass involving both orbits presenting with proptosis, and give a brief overview of the literature about this unusual entity. Rapid investigation and timely initiation of treatment are needed to salvage the eye and the vision. Orbital involvement is considered to confer a poorer prognosis to children with ALL.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Child
  • Exophthalmos
  • Female
  • Humans
  • Orbital Neoplasms / diagnostic imaging
  • Orbital Neoplasms / drug therapy*
  • Positron Emission Tomography Computed Tomography
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Treatment Outcome

Substances

  • Antineoplastic Agents