Polymorphism in phenobarbital: discovery of a new polymorph and crystal structure of elusive form V

Saikat Roy; N Rajesh Goud; Adam J Matzger

doi:10.1039/c6cc00959j

Polymorphism in phenobarbital: discovery of a new polymorph and crystal structure of elusive form V

Chem Commun (Camb). 2016 Mar 21;52(23):4389-92. doi: 10.1039/c6cc00959j.

Authors

Saikat Roy¹, N Rajesh Goud¹, Adam J Matzger²

Affiliations

¹ Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA. Matzger@umich.edu.
² Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA. Matzger@umich.edu and Macromolecular Science and Engineering, University of Michigan, 48109-1055, USA.

Abstract

This report highlights the discovery of a new polymorph of the anticonvulsant drug phenobarbital (PB) using polymer-induced heteronucleation (PIHn) and unravelling the crystal structure of the elusive form V. Both forms are characterized by structural, thermal and VT-Raman spectroscopy methods to elucidate phase transformation behavior and shed light on stability relationships.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Crystallography, X-Ray
Humans
Hydrogen Bonding
Phenobarbital / chemistry
Phenobarbital / pharmacology*
Polymorphism, Genetic*
Spectrum Analysis, Raman

Substances

Phenobarbital

Grants and funding

R01 GM106180/GM/NIGMS NIH HHS/United States