(Compl)Ex-Th17-Treg cell inter-relationship

Nataša Obermajer; Marc H Dahlke

doi:10.1080/2162402X.2015.1040217

(Compl)Ex-Th17-T_reg cell inter-relationship

Oncoimmunology. 2015 Apr 27;5(1):e1040217. doi: 10.1080/2162402X.2015.1040217. eCollection 2016.

Authors

Nataša Obermajer¹, Marc H Dahlke²

Affiliations

¹ Division of Surgical Oncology; University of Pittsburgh; Hillman Cancer Center ; Pittsburgh, PA, USA.
² Department of Surgery; University Medical Center Regensburg ; Regensburg, Germany.

Abstract

Codependent development and Th17-to-FoxP3⁺ T cell inter-conversion account for the enigmatic coexistence of IL17-producing and FoxP3⁺ cells in tumor-associated inflammation. In addition to T_reg cells, exTh17-FoxP3⁺ cells present a novel subpopulation of FoxP3⁺ cells. Yin-yang of IL17⁺ and FoxP3⁺ cells presents an important principle for improved approaches in cancer immunotherapy.

Keywords: T cell plasticity; Th17 cells; myeloid-derived suppressor cells; regulatory T cells; sterile inflammation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Grants and funding

P50 CA159981/CA/NCI NIH HHS/United States