Mitotic Mysteries: The Case of HP1

Jonathan M G Higgins; Lisa Prendergast

doi:10.1016/j.devcel.2016.02.019

Mitotic Mysteries: The Case of HP1

Dev Cell. 2016 Mar 7;36(5):477-8. doi: 10.1016/j.devcel.2016.02.019.

Authors

Jonathan M G Higgins¹, Lisa Prendergast²

Affiliations

¹ Cell Division Biology Research Group, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address: jonathan.higgins@ncl.ac.uk.
² Cell Division Biology Research Group, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

PMID: 26954539
DOI: 10.1016/j.devcel.2016.02.019

Abstract

The role of Heterochromatin Protein-1 (HP1) during mitosis has been controversial. Two recent studies in Science and Developmental Cell, from Tanno et al. (2015) and Abe et al. (2016), suggest that the means of HP1 localization and its function at inner centromeres are altered in cancer cells with chromosomal instability.

Publication types

Comment

MeSH terms

Carcinogenesis / metabolism*
Cell Cycle Proteins / metabolism*
Centromere / metabolism*
Chromosomal Instability*
Chromosome Segregation*
Humans

Substances

Cell Cycle Proteins