(Cell Metabolism 16, 613–624; November 7, 2012) In the article, we reported that the expression of a mitochondrial specific E3 ligase, Mul1, was induced in response to wasting conditions, and that increased Mul1 expression caused mitophagy and muscle wasting. Following an investigation by Nanyang Technological University, it was determined that the first author, Sudarsanareddy Lokireddy, falsified data in Figures 2D, 4B, 6D, 6E, and S5B. Although other work has linked Mul1 with mitophagy, in order to protect the integrity of science as well as of our laboratory and institutes, we are retracting the paper. We sincerely apologize to our colleagues and readers for any adverse consequences that this may have caused. The co-authors agree with this statement, with the exception of the first author, Sudarsanareddy Lokireddy.