Changes over lactation in breast milk serum proteins involved in the maturation of immune and digestive system of the infant

Lina Zhang; Marita de Waard; Hester Verheijen; Sjef Boeren; Jos A Hageman; Toon van Hooijdonk; Jacques Vervoort; Johannes B van Goudoever; Kasper Hettinga

doi:10.1016/j.dib.2016.02.046

Changes over lactation in breast milk serum proteins involved in the maturation of immune and digestive system of the infant

Data Brief. 2016 Feb 27:7:362-5. doi: 10.1016/j.dib.2016.02.046. eCollection 2016 Jun.

Authors

Lina Zhang¹, Marita de Waard², Hester Verheijen², Sjef Boeren³, Jos A Hageman⁴, Toon van Hooijdonk¹, Jacques Vervoort³, Johannes B van Goudoever⁵, Kasper Hettinga¹

Affiliations

¹ Dairy Science and Technology, Food Quality and Design group, Wageningen University, The Netherlands.
² Department of Paediatrics, VU University Medical Center, Amsterdam, The Netherlands.
³ Laboratory of Biochemistry, Wageningen University, The Netherlands.
⁴ Biometris-Applied Statistics, Wageningen University, The Netherlands; Centre for BioSystems Genomics, Wageningen University, The Netherlands.
⁵ Department of Paediatrics, VU University Medical Center, Amsterdam, The Netherlands; Academic Medical Center, Emma Children׳s Hospital, Amsterdam, The Netherlands.

Abstract

Here we provide data from shot-gun proteomics, using filtered-aided sample preparation (FASP), dimethyl labeling and LC-MS/MS, to quantify the changes in the repertoire of human milk proteins over lactation. Milk serum proteins were analyzed at week 1, 2, 3 4, 8, 16, and 24 in milk from four individual mothers. A total of 247 proteins were identified, of which 200 proteins were quantified. The data supplied in this article supports the accompanying publication (Zhang et al., 2006) [1]. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium (Vizcaíno et al., 2016) [2] via the PRIDE partner repository with the dataset identifier PXD003465.

Keywords: Gastrointestinal tract; Immune system; Milk serum proteome; Protease inhibitors.