A preoperative mathematic model for computed tomographic guided microwave ablation treatment of hepatic dome tumors

Oncotarget. 2016 May 3;7(18):25949-59. doi: 10.18632/oncotarget.8299.

Abstract

Purpose: This study sought to prospectively evaluate the feasibility and safety of a preoperative mathematic model for computed tomographic(CT) guided microwave(MW) ablation treatment of hepatic dome tumors.

Methods: This mathematic model was a regular cylinder quantifying appropriate puncture routes from the bottom up. A total of 103 patients with hepatic dome tumors were enrolled and randomly divided into 2 groups based on whether this model was used or not: Group A (using the model; n = 43) versus Group B (not using the model; n = 60). All tumors were treated by CT-guided MW ablation and follow-up contrast CT were reviewed.

Results: The average number of times for successful puncture, average ablation time, and incidence of right shoulder pain were less in Group A than Group B (1.4 vs. 2.5, P = 0.001; 8.8 vs. 11.1 minutes, P = 0.003; and 4.7% vs. 20%, P = 0.039). The technical success rate was higher in Group A than Group B (97.7% vs. 85.0%, P = 0.032). There were no significant differences between the two groups in primary and secondary technique efficacy rates (97.7% vs. 88.3%, P = 0.081; 90.0% vs. 72.7%, P = 0.314). No major complications occurred in both groups.

Conclusion: The mathematic model of regular cylinder is feasible and safe for CT-guided MW ablation in treating hepatic dome tumors.

Keywords: CT-guided; hepatic dome; mathematic model; microwave ablation; tumors.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Catheter Ablation / methods*
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / mortality
  • Liver Neoplasms / surgery*
  • Male
  • Microwaves / therapeutic use*
  • Middle Aged
  • Models, Theoretical*
  • Surgery, Computer-Assisted / methods*
  • Tomography, X-Ray Computed