Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing

Trends Genet. 2016 Jun;32(6):320-321. doi: 10.1016/j.tig.2016.03.006. Epub 2016 Apr 2.

Abstract

N(6)-Methyladenosine (m(6)A) is emerging as a chemical mark that broadly affects the flow of genetic information in various biological processes in eukaryotes. Recently, Xiao et al. reported that the nuclear m(6)A reader protein YTHDC1 impacts mRNA splicing, providing a transcriptome-wide glance of splicing changes affected by this mRNA methylation reader protein.

Keywords: N(6)-methyladenosine; YTHDC1; mRNA splicing.

Publication types

  • Comment

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / genetics
  • Eukaryota / genetics
  • Methylation
  • Nerve Tissue Proteins / genetics*
  • RNA Processing, Post-Transcriptional / genetics
  • RNA Splicing / genetics*
  • RNA Splicing Factors / genetics*
  • RNA, Messenger / genetics
  • Transcriptome / genetics

Substances

  • Nerve Tissue Proteins
  • RNA Splicing Factors
  • RNA, Messenger
  • YTHDC1 protein, human
  • N-methyladenosine
  • Adenosine