Case-centered Analysis of Optic Neuritis After Vaccines

Roger Baxter; Edwin Lewis; Bruce Fireman; Frank DeStefano; Julianne Gee; Nicola P Klein

doi:10.1093/cid/ciw224

Case-centered Analysis of Optic Neuritis After Vaccines

Clin Infect Dis. 2016 Jul 1;63(1):79-81. doi: 10.1093/cid/ciw224. Epub 2016 Apr 10.

Authors

Roger Baxter¹, Edwin Lewis¹, Bruce Fireman¹, Frank DeStefano², Julianne Gee², Nicola P Klein¹

Affiliations

¹ Northern California Kaiser Permanente Vaccine Study Center, Oakland.
² Centers for Disease Control and Prevention, Division of Healthcare Quality Promotion, Immunization Safety Office, Atlanta,Georgia.

PMID: 27069066
DOI: 10.1093/cid/ciw224

Abstract

We evaluated the risk of optic neuritis (ON) after vaccines, using a case-centered analysis, comparing the time since vaccination for the patients with ON with that for all similar vaccinees in a large integrated health plan population. We did not detect any association between ON and receipt of any type of vaccine.

Keywords: adverse event; immunization; optic neuritis; vaccine; vaccine safety.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adverse Drug Reaction Reporting Systems
Epidemiologic Research Design
Epidemiologic Studies
Humans
Optic Neuritis / epidemiology*
Optic Neuritis / etiology*
Vaccination / adverse effects
Vaccines / adverse effects*

Substances

Vaccines