Sweet Mitochondrial Dynamics in VMH Neurons

Sophie M Steculorum; Jens C Brüning

doi:10.1016/j.cmet.2016.03.014

Sweet Mitochondrial Dynamics in VMH Neurons

Cell Metab. 2016 Apr 12;23(4):577-9. doi: 10.1016/j.cmet.2016.03.014.

Authors

Sophie M Steculorum¹, Jens C Brüning²

Affiliations

¹ Max-Planck-Institute for Metabolism Research, Gleueler Strasse 50a, 50931 Köln, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing Associated Diseases (CECAD), Joseph-Stelzmann-Strasse 26, 50931 Köln, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital, Joseph-Stelzmann-Strasse 26, 50931 Köln, Germany.
² Max-Planck-Institute for Metabolism Research, Gleueler Strasse 50a, 50931 Köln, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing Associated Diseases (CECAD), Joseph-Stelzmann-Strasse 26, 50931 Köln, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital, Joseph-Stelzmann-Strasse 26, 50931 Köln, Germany. Electronic address: bruening@sf.mpg.de.

PMID: 27076074
DOI: 10.1016/j.cmet.2016.03.014

Abstract

The ventromedial nucleus of the hypothalamus (VMH) is a central region known to maintain glucose homeostasis. Toda et al. (2016) unravel a new mechanism underlying VMH-dependent regulation of systemic glucose homeostasis via uncoupling protein 2 (UCP2)-mediated control of mitochondrial dynamics and activation of glucose-excited neurons.

Publication types

Comment

MeSH terms

Animals
Cell Nucleus / metabolism*
Glucose / metabolism*
Ion Channels / metabolism*
Mitochondrial Dynamics*
Mitochondrial Proteins / metabolism*
Ventromedial Hypothalamic Nucleus / metabolism*

Substances

Ion Channels
Mitochondrial Proteins
Glucose