NMR relaxation of water in hydrogel polymers: a model for tissue

Magn Reson Med. 1989 Mar;9(3):325-32. doi: 10.1002/mrm.1910090304.

Abstract

The NMR relaxation rates of a class of hydrated polymers (hydrogels) have been investigated over a wide range of frequencies (0.01 to 60 MHz) and compositions. The gels comprise long chains of polytetramethylene oxide diol crosslinked by copolymers of dimethylacrylamide and methylmethacrylate. The longitudinal relaxation rate dispersion curves of these materials are very similar to those shown by human tissues and they can be altered in flexible fashion by changing the polymer content. By substitution of the water by deuterium oxide, the contribution of intermolecular cross-relaxation effects has been shown to account for two-thirds the total water relaxation rate. With their close similarity to tissue relaxation behavior, hydrogels of differing compositions are particularly well-suited to MRI phantoms and test objects.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Magnetic Resonance Spectroscopy*
  • Models, Structural*
  • Polyethylene Glycols*
  • Surface Properties
  • Water*

Substances

  • Water
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Polyethylene Glycols