Drug Delivery: Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery (Adv. Mater. 16/2016)

Yanqi Ye; Jicheng Yu; Chao Wang; Nhu-Y Nguyen; Glenn M Walker; John B Buse; Zhen Gu

doi:10.1002/adma.201670112

Drug Delivery: Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery (Adv. Mater. 16/2016)

Adv Mater. 2016 Apr;28(16):3223. doi: 10.1002/adma.201670112.

Authors

Yanqi Ye^{1

2}, Jicheng Yu^{1

2}, Chao Wang^{1

2}, Nhu-Y Nguyen¹, Glenn M Walker¹, John B Buse³, Zhen Gu^{1

2

3}

Affiliations

¹ Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.
² Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
³ Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.

PMID: 27105814
DOI: 10.1002/adma.201670112

Abstract

A bio-responsive microneedle-based patch, integrated with a rhodamine-stained glucose-signal amplifier and calcein-AM-stained pancreatic β-cell capsules, is developed by Z. Gu and co-workers. This "smart cell patch", described on page 3115, effectively regulates the blood glucose level of type-1 diabetic mice, achieving a reduction for over 10 h. Image credit: Yanqi Ye.

Keywords: diabetes; drug delivery; microneedles; pancreatic cells; physiological signals.