Neuroinflammation Regulates Cognitive Impairment in Socially Defeated Mice

Abstract

Impairments in memory and cognitive function are characteristic symptoms of stress-related disorders, but the relationship between stress and memory is complex. Recent findings suggest that hippocampal inflammatory processes contribute to spatial memory deficits in the rodent social defeat model that can be reversed by anti-inflammatory treatment with minocycline.

Keywords: Inflammation; memory; neurogenesis; stress.