Multifunctional quinoline-triazole derivatives as potential modulators of amyloid-β peptide aggregation

J Inorg Biochem. 2016 May:158:131-138. doi: 10.1016/j.jinorgbio.2016.04.022. Epub 2016 Apr 16.

Authors

Michael R Jones¹, Christine Dyrager¹, Marie Hoarau¹, Kyle J Korshavn², Mi Hee Lim³, Ayyalusamy Ramamoorthy⁴, Tim Storr⁵

Affiliations

¹ Department of Chemistry, Simon Fraser University, V5A-1S6 Burnaby, BC, Canada.
² Department of Chemistry, University of Michigan, Ann Arbor, USA.
³ Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea.
⁴ Department of Chemistry, University of Michigan, Ann Arbor, USA; Department of Biophysics, University of Michigan, Ann Arbor, USA.
⁵ Department of Chemistry, Simon Fraser University, V5A-1S6 Burnaby, BC, Canada. Electronic address: tim_storr@sfu.ca.

PMID: 27133802
DOI: 10.1016/j.jinorgbio.2016.04.022

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amyloid beta-Peptides / antagonists & inhibitors
Amyloid beta-Peptides / chemistry*
Coordination Complexes* / chemical synthesis
Coordination Complexes* / chemistry
Copper / chemistry*
Humans
Molecular Docking Simulation*
Peptide Fragments / antagonists & inhibitors
Peptide Fragments / chemistry*
Protein Aggregates*
Quinolones* / chemical synthesis
Quinolones* / chemistry
Triazoles* / chemical synthesis
Triazoles* / chemistry

Substances

Amyloid beta-Peptides
Coordination Complexes
Peptide Fragments
Protein Aggregates
Quinolones
Triazoles
amyloid beta-protein (1-42)
Copper