Abstract
Four new dianthrone glycosides, named polygonumnolides C1-C4 (1-4), were isolated from the dried roots of Polygonum multiflorum Thunb, together with two known emodin dianthrones (5-6). Their hepatotoxicities were evaluated against L-02 cell lines. Compounds 1-4 showed weak hepatotoxicity against L-02 cell lines with IC50 values of 313.05, 205.20, 294.20, and 207.35 μM, respectively.
Keywords:
L-02 cell lines; Polygonum multiflorum; dianthrone glycosides; polygonumnolides C1–C4.
MeSH terms
-
Anthracenes / chemistry
-
Anthracenes / isolation & purification*
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / isolation & purification*
-
Drugs, Chinese Herbal / pharmacology
-
Emodin / chemistry
-
Glycosides / chemistry
-
Glycosides / isolation & purification*
-
Humans
-
Liver / drug effects*
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Plant Roots / chemistry
-
Polygonum / chemistry*
-
Stereoisomerism
Substances
-
Anthracenes
-
Drugs, Chinese Herbal
-
Glycosides
-
Emodin