Nasopharyngeal Pneumococcal Serotypes Before and After Mass Azithromycin Distributions for Trachoma

Jeremy D Keenan; Ida Sahlu; Lesley McGee; Vicky Cevallos; Jorge E Vidal; Sopio Chochua; Paulina Hawkins; Teshome Gebre; Zerihun Tadesse; Paul M Emerson; Bruce D Gaynor; Thomas M Lietman; Keith P Klugman

doi:10.1093/jpids/piu143

Nasopharyngeal Pneumococcal Serotypes Before and After Mass Azithromycin Distributions for Trachoma

J Pediatric Infect Dis Soc. 2016 Jun;5(2):222-6. doi: 10.1093/jpids/piu143. Epub 2015 Jan 30.

Authors

Affiliations

¹ Francis I Proctor Foundation, University of California, San Francisco Department of Ophthalmology, University of California, San Francisco.
² Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.
³ Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
⁴ Francis I Proctor Foundation, University of California, San Francisco.
⁵ Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
⁶ The Carter Center, Addis Ababa, Ethiopia.
⁷ The Carter Center, Atlanta, Georgia.

Abstract

Twenty-four Ethiopian communities were randomized to receive either (1) quarterly mass azithromycin distributions for trachoma for 1 year or (2) delayed treatment. Nasopharyngeal swabs collected from separate cross-sectional population-based samples of children were processed for Streptococcus pneumoniae Mass azithromycin did not significantly alter the pneumococcal serotype distribution, and hence it would not be expected to alter vaccine coverage.

Keywords: Africa; Streptococcus pneumoniae; pneumococcal vaccines; serotype.

Publication types

Randomized Controlled Trial

MeSH terms

Anti-Bacterial Agents / administration & dosage*
Azithromycin / administration & dosage*
Carrier State
Child
Child, Preschool
Cross-Sectional Studies
Ethiopia
Humans
Infant
Pneumococcal Infections / epidemiology*
Serogroup
Streptococcus pneumoniae / classification*
Trachoma / prevention & control*

Substances

Anti-Bacterial Agents
Azithromycin

Abstract

Publication types

MeSH terms

Substances

Grants and funding