Advanced Genetic Methodologies in Tracking Evolution and Spread of Chikungunya Virus

Methods Mol Biol. 2016:1426:21-37. doi: 10.1007/978-1-4939-3618-2_3.

Abstract

Recent advances in genetic methodologies have substantially expanded our ability to track evolution and spatio-temporal distribution of rapidly evolving pathogens. The information gathered from such analyses can be used to decipher host adaptations that shape disease epidemiology. In this chapter, we demonstrate the utilization of freely available resources to track the evolution and spread of Chikungunya virus.

Keywords: Chikungunya virus; Common ancestor; Evolution; Evolutionary network; Multiple alignment; Phylogenetics; Phylogeography.

MeSH terms

  • Chikungunya virus / classification*
  • Chikungunya virus / genetics*
  • Evolution, Molecular
  • Mutation Rate
  • Phylogeny
  • Phylogeography
  • Polymorphism, Single Nucleotide
  • RNA, Viral / genetics*

Substances

  • RNA, Viral