Fatal methotrexate toxicity in a patient treated for an ectopic pregnancy

Emna Gaïes; Mouna Ben Sassi; Rim Charfi; Mohamed Lakhal; Anis Klouz; Sameh Trabelsi; Issam Salouage

doi:10.1016/j.therap.2015.12.006

Fatal methotrexate toxicity in a patient treated for an ectopic pregnancy

Therapie. 2016 Jun;71(3):348-50. doi: 10.1016/j.therap.2015.12.006. Epub 2016 Feb 15.

Authors

Emna Gaïes¹, Mouna Ben Sassi², Rim Charfi¹, Mohamed Lakhal¹, Anis Klouz¹, Sameh Trabelsi¹, Issam Salouage¹

Affiliations

¹ Department of clinical pharmacology, national centre of pharmacovigilance, 9, avenue Dr. Zouheir Essafi, 1006 Tunis, Tunisia.
² Department of clinical pharmacology, national centre of pharmacovigilance, 9, avenue Dr. Zouheir Essafi, 1006 Tunis, Tunisia. Electronic address: mouna.bs@hotmail.fr.

PMID: 27235664
DOI: 10.1016/j.therap.2015.12.006

No abstract available

Keywords: Ectopic pregnancy; Effets indésirables; Grossesse extra-utérine; Methotrexate; Méthotrexate; Side effects; Suivi thérapeutique pharmacologique; Therapeutic drug monitoring; Toxicity; Toxicité.

Publication types

Case Reports
Letter

MeSH terms

Abortifacient Agents, Nonsteroidal / administration & dosage
Abortifacient Agents, Nonsteroidal / adverse effects*
Adult
Fatal Outcome
Female
Humans
Injections, Intramuscular
Methotrexate / administration & dosage
Methotrexate / adverse effects*
Pancytopenia / chemically induced*
Pregnancy
Pregnancy, Ectopic / drug therapy*

Substances

Abortifacient Agents, Nonsteroidal
Methotrexate