Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression

Claire Vennin; David Herrmann; Morghan C Lucas; Paul Timpson

doi:10.12688/f1000research.8090.1

Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression

F1000Res. 2016 May 16:5:F1000 Faculty Rev-892. doi: 10.12688/f1000research.8090.1. eCollection 2016.

Authors

Claire Vennin^#^{1

2}, David Herrmann^#^{1

2}, Morghan C Lucas^{1

2}, Paul Timpson^{1

2}

Affiliations

¹ The Kinghorn Cancer Centre, Cancer Division, The Garvan Institute of Medical Research, Sydney, NSW, Australia.
² St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.

^# Contributed equally.

Abstract

Intravital imaging is providing new insights into the dynamics of tumor progression in native tissues and has started to reveal the layers of complexity found in cancer. Recent advances in intravital imaging have allowed us to look deeper into cancer behavior and to dissect the interactions between tumor cells and the ancillary host niche that promote cancer development. In this review, we provide an insight into the latest advances in cancer biology achieved by intravital imaging, focusing on recently discovered mechanisms by which tumor cells manipulate normal tissue to facilitate disease progression.

Keywords: Intravital imaging; tumor progression.

Publication types

Review

Grants and funding

Claire Vennin, David Herrmann, Morghan C. Lucas, and Paul Timpson were funded by an NHMRC project grant, an ARC Future and a Len Ainsworth Pancreatic Cancer Fellowship, the Cancer Council NSW, and a Tour de Cure grant.