Abstract
The blaIMP-14 carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli, we identified a sequence type 131 strain harboring blaIMP-14 within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C2 plasmid. The emergence of blaIMP-14 in this context in the ST131 lineage is of potential clinical concern.
Copyright © 2016 Stoesser et al.
MeSH terms
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Acinetobacter / drug effects
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Acinetobacter / enzymology
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Acinetobacter / genetics
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Anti-Bacterial Agents / pharmacology
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Carbapenems / pharmacology
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Drug Resistance, Multiple, Bacterial / genetics
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Escherichia coli / drug effects*
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Escherichia coli / enzymology*
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Escherichia coli / genetics
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Integrons / genetics
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Microbial Sensitivity Tests
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Plasmids / genetics*
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / enzymology
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Pseudomonas aeruginosa / genetics
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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Carbapenems
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beta-Lactamases