Epistatic interaction between MyD88 and TIRAP against Helicobacter pylori

FEBS Lett. 2016 Jul;590(14):2127-37. doi: 10.1002/1873-3468.12252. Epub 2016 Jun 27.

Abstract

The genes MyD88 and TIRAP encode the adaptor proteins MyD88 and TIRAP. TIRAP plays the crucial role of activating the MyD88-dependent pathway, which in turn controls the immune response (innate and adaptive) to Helicobacter pylori. We looked for an association of MyD88 and TIRAP with H. pylori infection. Cases and controls were genotyped at the polymorphic sites MyD88 rs6853 and TIRAP rs8177374 by real-time PCR. When the genes were analyzed separately, only TIRAP was associated with infection. When the genes were analyzed concurrently, certain combinations of MyD88 and TIRAP protected the host against H. pylori colonization more efficiently than could be done by TIRAP alone.

Keywords: Helicobacter pylori; MyD88; TIRAP; epistasis.

Publication types

  • Letter

MeSH terms

  • Adult
  • Epistasis, Genetic / immunology*
  • Female
  • Helicobacter Infections* / genetics
  • Helicobacter Infections* / immunology
  • Helicobacter pylori / immunology*
  • Humans
  • Male
  • Membrane Glycoproteins* / genetics
  • Membrane Glycoproteins* / immunology
  • Middle Aged
  • Myeloid Differentiation Factor 88* / genetics
  • Myeloid Differentiation Factor 88* / immunology
  • Polymorphism, Genetic / immunology*
  • Receptors, Interleukin-1* / genetics
  • Receptors, Interleukin-1* / immunology

Substances

  • MYD88 protein, human
  • Membrane Glycoproteins
  • Myeloid Differentiation Factor 88
  • Receptors, Interleukin-1
  • TIRAP protein, human