Linkage analysis with inbreeding

Genet Epidemiol. 1989;6(1):277-9. doi: 10.1002/gepi.1370060148.

Abstract

For computational reasons, linkage analysis of highly inbred pedigrees is often performed under the assumption that spouse pairs are genetically unrelated. A formulation of the likelihood of a pedigree which takes into account all of the genealogical information omega, for an arbitrary relationship between a pair of spouses, is proposed. Lod scores at a recombination fraction of 0 for an inbred three-member nuclear family are presented.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Child
  • Computer Simulation
  • Consanguinity*
  • Genetic Linkage*
  • Genotype
  • Humans
  • Pedigree